Not safe even under 35 years of age: possible chromosomal abnormalities in NIPT

Not safe even under 35 years of age: possible chromosomal abnormalities in NIPT

Do people under 35 years old have to undergo NIPT? I am sure that my baby will be born healthy! But I'm really worried if it's OK...
Whether it is her first pregnancy or not, pregnant women are always both joyful and anxious. Below are the frequencies and ages of chromosomal abnormalities.

Does a person under 35 years of age have to take NIPT?

I am sure my baby will be born healthy! But I'm really worried... Whether it is your first pregnancy or not, pregnant women are always both happy and anxious.

The baby is in the mother's belly for about 10 months. Although there are various people who may feel that this pregnancy period is long or short, everyone wants to have a safe and comfortable life as an expectant mother.

NIPT (New Inclusive Prenatal Test) is for pregnant women who want to eliminate some of the uncertainties of such a short but long pregnancy period. The number of people undergoing this NIPT test is increasing every year.

However, NIPT testing is only available at accredited facilities to those who are 35 years of age or older. Does this mean that people under 35 years of age do not need to take the test?

Frequency of Chromosomal Aberrations and Age

Pregnant age Frequency of children born with Down syndrome (per thousand live births)Frequency of births with any chromosomal abnormality (thousands of births)
20 years old out of 1/1667 (0.6) Out of 1/526 (1.9)
25 years old Out of 1/1250 (0.8) Of 1/476 (2.1)
30 years old Out of 1/952 (1.1) out of 1/384 (2.6)
31 years old Out of 1/909 (1.1) out of 1/384 (2.6)
32 years old Out of 1/769 (1.3) Out of 1/323 (3.1)
33 years old Of 1/625 (1.6) Out of 1/286 (3.5)
34 years old 1 person/out of 500 (2.0) Out of 1/238 (4.2)
35 years old Out of 1/385 (2.6) Out of 1/192 (5.2)
36 years old out of 1/294 (3.4) out of 1/156 (6.4)
37 years old Out of 1/227 (4.4) Out of 1/127 (7.9)
38 years old Out of 1/175 (5.7) Out of 1/102 (9.8)
39 years old Out of 1/137 (7.3) out of 1/83 (12.0)
40 years old Out of 1/106 (9.4) out of 1/66 (15.2)
41 years old. 1 person/out of 82 (12.2) out of 1/53 (18.9)
42 years old Out of 1/64 (15.6) Out of 1/42 (23.8)
43 years old 1 person/out of 50 (20.0) Out of 1/53 (30.3)
44 years old 1 person/out of 38 (26.3) Out of 1/26 (38.5)
45 years old 1 person/out of 30 (33.3) Out of 1/21 (47.6)
46 years old 1 person/23 out of 23 (43.5) Out of 1/16 (62.5)
47 years old 1 person/18 out of 18 (55.6) Out of 1/13 (76.9)
48 years old out of 1/14 (71.4) Out of 1/10 (100.0)
49 years old 1 person/11 out of 11 (90.9) In 1/8 (125.0)

As you can see from the table above, the probability of giving birth to a child with Down syndrome or some other chromosomal abnormality increases with age. However, it is not a sharp increase from the age of 35, and the probability is not zero even for those under 35.

Chromosomal abnormalities are not only a risk for women.

Although women's age is often the only factor that is discussed in the media when it comes to pregnancy and childbirth, men's age is also a factor. According to an American study, men over the age of 35 are at increased risk for genetic mutations.

Because male sperm undergo many repeated cell divisions, they are prone to genetic mutations, and age-related aging can lead to abnormalities. It is said that brain dysfunctions such as autism increase when the father is elderly, and children with chromosomal abnormalities such as Down syndrome increase when the mother is elderly.

Even if the mother's age is under 35, caution may be necessary if the father's age is over 35.

To be tested for NIPT under 35 years of age

In the United States, it is recommended that pregnant women of all ages undergo NIPT testing, and it is a common test regardless of age.

If you are under 35 years of age and wish to undergo NIPT testing, you will be tested at a non-accredited facility. There is no significant difference in test results between accredited and non-accredited facilities. Before worrying about your concerns, why don't you contact us first?