◆POC (miscarriage chorion chromosome test)

Human cells contain a total of 46 chromosomes of paternal and maternal origin. Chromosome aneuploidy that occurs prior to implantation can cause miscarriage or difficulty in continuing a pregnancy; the POC test examines fetal tissue after miscarriage to determine chromosome aneuploidy in those who have experienced repeated miscarriages or are undergoing assisted reproductive technology.

It is estimated that 15-20% of human pregnancies result in miscarriage, and the rate is as high as 1 in 5-6, especially among young people. The primary cause is an "accidental" numerical chromosomal abnormality, which is not associated with disease or genetic disorders. However, in the case of repeat miscarriages, there may be other causes than accidental errors.

Miscarriage chorionic staining (POC) is performed as a means of identifying the cause of repeat miscarriages. POC provides important information for future treatment planning.

◆Benefits of POC testing

◆Test results and treatment progression


Due to the limited amount of fetal tissue, reliable selection of the trophoblastic portion is necessary, and attention should be paid to maternal blood contamination and the difficulty of obtaining uterine contents. Early submission is desirable, and chorionic villi tissue should be preserved to avoid freezing; POC testing is not covered by insurance and is an expensive patient expense. If interpretation of results is difficult, referral to a specialized facility with reproductive and perinatal genetic medicine capabilities is recommended; POC testing includes not only numerical chromosomal abnormalities, but also mosaicism, marker chromosomes, and structural abnormalities, requiring genetic medicine expertise.